Photodynamic therapy light dose analysis of a patient based upon arterial and venous contrast CT scan information

Michael Jermyn; Scott C. Davis; Hamid Dehghani; Matthew Huggett; Tayyaba Hasan; Stephen P. Pereira; Brian W. Pogue

doi:10.1117/12.2004003

13 March 2013 Photodynamic therapy light dose analysis of a patient based upon arterial and venous contrast CT scan information

Michael Jermyn, Scott C. Davis, Hamid Dehghani, Matthew Huggett, Tayyaba Hasan, Stephen P. Pereira, Brian W. Pogue

Author Affiliations +

Proceedings Volume 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII; 85680Z (2013) https://doi.org/10.1117/12.2004003
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

The goal of this work was to determine the light dose required to induce necrosis in verteporfin-based photodynamic therapy, in the VERTPAC-1 trial. Patient CT scans were obtained of the abdomen, including the entire treatment zone of pancreas and surrounding tissues, before and after treatment, as well as fast scans during needle placement. These scans were used to estimate arterial and venous blood content, and provide structural information of the pancreas and nearby blood vessels. Using NIRFAST, a finite-element based package for modeling diffuse near-infrared light transport in tissue, simulations were run to create maps of light fluence within the pancreas. These maps provided visualizations of light dose overlaid on the original CT scans, and were used to estimate light dose at the boundary of the zone of necrosis, as observed in follow up treatment outcome CT scans. The aim of these simulation studies was to assist pre-treatment planning by informing the light treatment parameters. This paper presents a case study of the process used on a single patient.

Citation Download Citation

Michael Jermyn, Scott C. Davis, Hamid Dehghani, Matthew Huggett, Tayyaba Hasan, Stephen P. Pereira, and Brian W. Pogue "Photodynamic therapy light dose analysis of a patient based upon arterial and venous contrast CT scan information ", Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85680Z (13 March 2013); https://doi.org/10.1117/12.2004003

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available