13 March 2013 Monitoring PDT response of head and neck lesions with diffuse optical spectroscopies
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Abstract
Photodynamic therapy (PDT) has recently emerged as a potential treatment alternative for head and neck cancer. There is strong evidence that imprecise PDT dosimetry results in variations in clinical responses. Quantitative tools are likely to play an essential role in bringing PDT to a full realization of its potential benefits. They can provide standardization of site-specific individualized protocols that are used to monitor both light and photosensitizer (HPPH) dose, as well as the tissue response for individual patients. To accomplish this, we used a custom instrument and a hand-held probe that allowed quantification of blood flow, blood volume, blood oxygen saturation and drug concentration.
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Daniel J. Rohrbach, Daniel J. Rohrbach, Nestor Rigual, Nestor Rigual, Erin Tracy, Erin Tracy, Ken Keymel, Ken Keymel, Michele T. Cooper, Michele T. Cooper, Heinz Baumann, Heinz Baumann, Barbara W. Henderson, Barbara W. Henderson, Ulas Sunar, Ulas Sunar, } "Monitoring PDT response of head and neck lesions with diffuse optical spectroscopies", Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 856814 (13 March 2013); doi: 10.1117/12.2005024; https://doi.org/10.1117/12.2005024
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