A probe specific empirical light transport model for improved
quantification of optical parameters for accurate PDT dosimetry

Daniel J. Rohrbach; Andrew Kowalczewski; Bouri Chen; Ulas Sunar

doi:10.1117/12.2005051

13 March 2013 A probe specific empirical light transport model for improved quantification of optical parameters for accurate PDT dosimetry

Daniel J. Rohrbach, Andrew Kowalczewski, Bouri Chen, Ulas Sunar

Author Affiliations +

Proceedings Volume 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII; 856815 (2013) https://doi.org/10.1117/12.2005051
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Diffuse reflectance spectroscopy (DRS) is a common technique for assessing tissue optical parameters (absorption, scattering) non-invasively. However, choosing the correct model for light-tissue interaction is needed for accurate quantification. The diffusion approximation is only valid for certain ranges of tissue optical properties and specific probe geometries. For improved quantification with DRS over a wide range of optical properties and for a short source detector separation, a probe-specific light transport model can provide more accurate analysis of optical parameters. We developed and tested a probe-specific empirical model by using tissue simulating phantoms with promising results. We will apply it for the analysis of patients from a clinical trial for head and neck cancer.

Citation Download Citation

Daniel J. Rohrbach, Andrew Kowalczewski, Bouri Chen, and Ulas Sunar "A probe specific empirical light transport model for improved quantification of optical parameters for accurate PDT dosimetry", Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 856815 (13 March 2013); https://doi.org/10.1117/12.2005051

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