13 March 2013 A probe specific empirical light transport model for improved quantification of optical parameters for accurate PDT dosimetry
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Abstract
Diffuse reflectance spectroscopy (DRS) is a common technique for assessing tissue optical parameters (absorption, scattering) non-invasively. However, choosing the correct model for light-tissue interaction is needed for accurate quantification. The diffusion approximation is only valid for certain ranges of tissue optical properties and specific probe geometries. For improved quantification with DRS over a wide range of optical properties and for a short source detector separation, a probe-specific light transport model can provide more accurate analysis of optical parameters. We developed and tested a probe-specific empirical model by using tissue simulating phantoms with promising results. We will apply it for the analysis of patients from a clinical trial for head and neck cancer.
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Daniel J. Rohrbach, Daniel J. Rohrbach, Andrew Kowalczewski, Andrew Kowalczewski, Bouri Chen, Bouri Chen, Ulas Sunar, Ulas Sunar, } "A probe specific empirical light transport model for improved quantification of optical parameters for accurate PDT dosimetry", Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 856815 (13 March 2013); doi: 10.1117/12.2005051; https://doi.org/10.1117/12.2005051
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