13 March 2013 An ultrasound-guided fluorescence tomography system: design and specification
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Abstract
An ultrasound-guided fluorescence molecular tomography system is under development for in vivo quantification of Protoporphyrin IX (PpIX) during Aminolevulinic Acid - Photodynamic Therapy (ALA-PDT) of Basal Cell Carcinoma. The system is designed to combine fiber-based spectral sampling of PPIX fluorescence emission with co-registered ultrasound images to quantify local fluorophore concentration. A single white light source is used to provide an estimate of the bulk optical properties of tissue. Optical data is obtained by sequential illumination of a 633nm laser source at 4 linear locations with parallel detection at 5 locations interspersed between the sources. Tissue regions from segmented ultrasound images, optical boundary data, white light-informed optical properties and diffusion theory are used to estimate the fluorophore concentration in these regions. Our system and methods allow interrogation of both superficial and deep tissue locations up to PpIX concentrations of 0.025ug/ml.
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Alisha V. D'Souza, Alisha V. D'Souza, Brendan P. Flynn, Brendan P. Flynn, Stephen C. Kanick, Stephen C. Kanick, Sason Torosean, Sason Torosean, Scott C. Davis, Scott C. Davis, Edward V. Maytin, Edward V. Maytin, Tayyaba Hasan, Tayyaba Hasan, Brian W. Pogue, Brian W. Pogue, } "An ultrasound-guided fluorescence tomography system: design and specification", Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85681A (13 March 2013); doi: 10.1117/12.2007504; https://doi.org/10.1117/12.2007504
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