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5 March 2013 Use of laser photomodulation in the evolution of oral mucositis associated to cyclophosphamide, methotrexate, 5-fluouracil - CMF in 5 fluouracil + adriamycin + cyclophosphamide - FAC chemotherapy protocols in patients with breast cancer
Maria de Fátima Lima Ferreira, Fabiola Bastos de Carvalho, Susana C. P. S. de Oliveira, Juliana S. C. Monteiro, Gustavo M. P. Santos, Maria F. M. Gesteira, Tereza Cristina Teixeira Maia, Antônio L. B. Pinheiro
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Proceedings Volume 8569, Mechanisms for Low-Light Therapy VIII; 85690O (2013) https://doi.org/10.1117/12.2005274
Event: SPIE BiOS, 2013, San Francisco, California, United States
Abstract
The aim of this study was to evaluate the efficacy of the laser photobiomodulation (FBML) in prevention and treatment of oral mucositis induced by chemotherapy protocols CMF (cyclophosphamide, methotrexate, 5-Fluouracil) and FAC (5 Fluouracil + Adriamycin + Cyclophosphamide) in cancer patients breast. We selected 28 patients treated at the Center for High Complexity (CACON), who underwent 6 cycles of 21 days of treatment, with diagnosis of infiltrating ductal carcinoma (ICD C50.9). Were randomly divided into three groups: Group A - eight patients (Protocol FAC + Dental protocol of CACON + Laser), Group B - 6 patients (Protocol CMF + Dental protocol of CACON + Laser), Group C - was divided into two sub-groups: Group C1 with 8 patients (Control Group 1: FAC + Dental protocol o CACON) and group C2 with 6 patients (control group 2: Protocol CMF + Dental protocol of CACON). Patients in Group A and B were use of preventive FBML 24 hours before the start of chemotherapy cycle, then every 48 hours and was extended up to one week following completion of chemotherapy. The groups A and B, presented oral mucositis grade 0 (64.29%) p = 0.07, grade I (7.14%), grade II (14.29%), grade III (7.14 %), grade IV (7.14%) compared to group C, who presented mucositis grade 0 (35.71%) in the initial evaluation with p = 0.10, grade I (21.43%), grade II (28.57%), grade III (14.29%), grade IV (0.00%), patients who used the FBML as a preventive and therapeutic showed a reduction and pain relief in 42.86%. It is concluded that the low power laser when used preventively or as therapy and showed immediate relief of pain and accelerate tissue repair.
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Maria de Fátima Lima Ferreira, Fabiola Bastos de Carvalho, Susana C. P. S. de Oliveira, Juliana S. C. Monteiro, Gustavo M. P. Santos, Maria F. M. Gesteira, Tereza Cristina Teixeira Maia, and Antônio L. B. Pinheiro "Use of laser photomodulation in the evolution of oral mucositis associated to cyclophosphamide, methotrexate, 5-fluouracil - CMF in 5 fluouracil + adriamycin + cyclophosphamide - FAC chemotherapy protocols in patients with breast cancer", Proc. SPIE 8569, Mechanisms for Low-Light Therapy VIII, 85690O (5 March 2013); https://doi.org/10.1117/12.2005274
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KEYWORDS
Electronic filtering
Laser therapeutics
Breast cancer
Cancer
Oncology
Laser dentistry
Laser induced plasma spectroscopy
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