Characterization of ovarian tissue using polarization-sensitive optical coherence tomography

Tianheng Wang; Yi Yang; Xiaohong Wang; Melinda Sanders; Molly Brewer; Quing Zhu

doi:10.1117/12.2001515

20 March 2013 Characterization of ovarian tissue using polarization-sensitive optical coherence tomography

Tianheng Wang, Yi Yang, Xiaohong Wang, Melinda Sanders, Molly Brewer, Quing Zhu

Proceedings Volume 8571, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII; 857124 (2013) https://doi.org/10.1117/12.2001515
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

We characterized ovarian tissue by using polarization-sensitive optical coherence tomography (PS-OCT). Phase retardation changing rate along with optical scattering coefficient and phase retardation were extracted from 33 ex vivo human ovaries from 18 patients. By using phase retardation changing rate as a classifier, we could achieve 71% sensitivity and 100% specificity. Combining those three parameters together, we could achieve 100% sensitivity and 100% specificity. These initial results showed that the quantitative analysis of PS-OCT could be a useful tool to characterize normal and malignant ovarian tissue.

Citation Download Citation

Tianheng Wang, Yi Yang, Xiaohong Wang, Melinda Sanders, Molly Brewer, and Quing Zhu "Characterization of ovarian tissue using polarization-sensitive optical coherence tomography", Proc. SPIE 8571, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII, 857124 (20 March 2013); https://doi.org/10.1117/12.2001515

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