20 March 2013 Combining a focused air-puff system with phase-sensitive optical coherence tomography for the detection of soft-tissue tumors based on elasticity measurement
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Abstract
We combine a focused air-puff system with phase-sensitive optical coherence tomography (PhS-OCT) to measure the elasticity of soft tissues. Surface waves (SWs) on soft tissues are induced by a low-pressure, short-duration air stream from an air-puff system and measured using a high-sensitivity PhS-OCT imaging system. Young’s modulus of soft tissues can be quantified based on the group velocity of SWs. To precisely control the excitation pressure, the air-puff system was characterized with a high-resolution analog pressure transducer. We studied the feasibility of this method for the non-contact detection of soft-tissue tumors. Ex vivo human fat and myxoma were used for these pilot experiments. Results demonstrate that this optical non-contact technique can be used to differentiate soft-tissue tumors from normal tissues based on measurements of their elasticity.
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Shang Wang, Shang Wang, Jiasong Li, Jiasong Li, Srilatha Vantipalli, Srilatha Vantipalli, Ravi Kiran Manapuram, Ravi Kiran Manapuram, Davis R. Ingram, Davis R. Ingram, Michael D. Twa, Michael D. Twa, Alexander J. Lazar, Alexander J. Lazar, Dina C. Lev, Dina C. Lev, Raphael E. Pollock, Raphael E. Pollock, Kirill V. Larin, Kirill V. Larin, } "Combining a focused air-puff system with phase-sensitive optical coherence tomography for the detection of soft-tissue tumors based on elasticity measurement", Proc. SPIE 8571, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII, 85712B (20 March 2013); doi: 10.1117/12.2007156; https://doi.org/10.1117/12.2007156
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