Non-contact tissue perfusion and oxygenation imaging using a LED based multispectral and a thermal imaging system, first results of clinical intervention studies

John H. G. M. Klaessens; Martin Nelisse; Rudolf M. Verdaasdonk; Herke Jan Noordmans

doi:10.1117/12.2003807

22 March 2013 Non-contact tissue perfusion and oxygenation imaging using a LED based multispectral and a thermal imaging system, first results of clinical intervention studies

John H. G. M. Klaessens, Martin Nelisse, Rudolf M. Verdaasdonk, Herke Jan Noordmans

Author Affiliations +

Proceedings Volume 8572, Advanced Biomedical and Clinical Diagnostic Systems XI; 857207 (2013) https://doi.org/10.1117/12.2003807
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

During clinical interventions objective and quantitative information of the tissue perfusion, oxygenation or temperature can be useful for the surgical strategy. Local (point) measurements give limited information and affected areas can easily be missed, therefore imaging large areas is required. In this study a LED based multispectral imaging system (MSI, 17 different wavelengths 370nm-880nm) and a thermo camera were applied during clinical interventions: tissue flap transplantations (ENT), local anesthetic block and during open brain surgery (epileptic seizure). The images covered an area of 20x20 cm, when doing measurements in an (operating) room, they turned out to be more complicated than laboratory experiments due to light fluctuations, movement of the patient and limited angle of view. By constantly measuring the background light and the use of a white reference, light fluctuations and movement were corrected. Oxygenation concentration images could be calculated and combined with the thermal images. The effectively of local anesthesia of a hand could be predicted in an early stage using the thermal camera and the reperfusion of transplanted skin flap could be imaged. During brain surgery, a temporary hyper-perfused area was witnessed which was probably related to an epileptic attack. A LED based multispectral imaging system combined with thermal imaging provide complementary information on perfusion and oxygenation changes and are promising techniques for real-time diagnostics during clinical interventions.

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John H. G. M. Klaessens, Martin Nelisse, Rudolf M. Verdaasdonk, and Herke Jan Noordmans "Non-contact tissue perfusion and oxygenation imaging using a LED based multispectral and a thermal imaging system, first results of clinical intervention studies", Proc. SPIE 8572, Advanced Biomedical and Clinical Diagnostic Systems XI, 857207 (22 March 2013); https://doi.org/10.1117/12.2003807

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