A method to visualize lipid distribution within arterial vessel walls by 1.7 µm spectroscopic spectral-domain optical coherence tomography

Mitsuharu Hirano; Ichiro Sogawa; Takemi Hasegawa; Masato Tanaka

doi:10.1117/12.2003700

22 March 2013 A method to visualize lipid distribution within arterial vessel walls by 1.7 μm spectroscopic spectral-domain optical coherence tomography

Mitsuharu Hirano, Ichiro Sogawa, Takemi Hasegawa, Masato Tanaka

Author Affiliations +

Proceedings Volume 8572, Advanced Biomedical and Clinical Diagnostic Systems XI; 85720E (2013) https://doi.org/10.1117/12.2003700
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

We report a method to visualize lipid distribution in axial and lateral direction within arterial vessel walls by spectroscopic spectral-domain Optical Coherence Tomography (OCT) at 1.7 μm wavelength for identification of lipidrich plaque. An OCT interferometric spectrum, after divided into several subbands for each of which A-scan profile is calculated, are fitted to a model accounting the contributions from absorption and scattering, with assumption that lipid content changes slowly in space, and lipid distribution is visualized. We investigated numerically the effects of analyzing parameters on the performance of lipid detection using simulated OCT data, and have found optimum parameters.

Citation Download Citation

Mitsuharu Hirano, Ichiro Sogawa, Takemi Hasegawa, and Masato Tanaka "A method to visualize lipid distribution within arterial vessel walls by 1.7 μm spectroscopic spectral-domain optical coherence tomography", Proc. SPIE 8572, Advanced Biomedical and Clinical Diagnostic Systems XI, 85720E (22 March 2013); https://doi.org/10.1117/12.2003700

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