22 March 2013 A method to visualize lipid distribution within arterial vessel walls by 1.7 μm spectroscopic spectral-domain optical coherence tomography
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Abstract
We report a method to visualize lipid distribution in axial and lateral direction within arterial vessel walls by spectroscopic spectral-domain Optical Coherence Tomography (OCT) at 1.7 μm wavelength for identification of lipidrich plaque. An OCT interferometric spectrum, after divided into several subbands for each of which A-scan profile is calculated, are fitted to a model accounting the contributions from absorption and scattering, with assumption that lipid content changes slowly in space, and lipid distribution is visualized. We investigated numerically the effects of analyzing parameters on the performance of lipid detection using simulated OCT data, and have found optimum parameters.
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Mitsuharu Hirano, Mitsuharu Hirano, Ichiro Sogawa, Ichiro Sogawa, Takemi Hasegawa, Takemi Hasegawa, Masato Tanaka, Masato Tanaka, "A method to visualize lipid distribution within arterial vessel walls by 1.7 μm spectroscopic spectral-domain optical coherence tomography", Proc. SPIE 8572, Advanced Biomedical and Clinical Diagnostic Systems XI, 85720E (22 March 2013); doi: 10.1117/12.2003700; https://doi.org/10.1117/12.2003700
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