13 March 2013 Validation of diffuse optical tomography using a bi-functional optical-MRI contrast agent and a hybrid MRI-DOT system
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Proceedings Volume 8574, Multimodal Biomedical Imaging VIII; 85740K (2013) https://doi.org/10.1117/12.2003606
Event: SPIE BiOS, 2013, San Francisco, California, United States
Abstract
Since diffuse optical tomography (DOT) is a low spatial resolution modality, it is desirable to validate its quantitative accuracy with another well-established imaging modality, such as magnetic resonance imaging (MRI). In this work, we have used a polymer based bi-functional MRI-optical contrast agent (Gd-DTPA-polylysine-IR800) in collaboration with GE Global Research. This multi-modality contrast agent provided not only co-localization but also the same kinetics, to cross-validate two imaging modalities. Bi-functional agents are injected to the rats and pharmacokinetics at the bladder are recovered using both optical and MR imaging. DOT results are validated using MRI results as "gold standard"
© (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Alex T. Luk, Alex T. Luk, Yuting Lin, Yuting Lin, Brian Grimmond, Brian Grimmond, Anup Sood, Anup Sood, Egidijus E. Uzgiris, Egidijus E. Uzgiris, Orhan Nalcioglu, Orhan Nalcioglu, Gultekin Gulsen, Gultekin Gulsen, } "Validation of diffuse optical tomography using a bi-functional optical-MRI contrast agent and a hybrid MRI-DOT system", Proc. SPIE 8574, Multimodal Biomedical Imaging VIII, 85740K (13 March 2013); doi: 10.1117/12.2003606; https://doi.org/10.1117/12.2003606
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