Ultra-high sensitivity detection of bimodal probes at ultra-low noise for combined fluorescence and positron emission tomography imaging

Réjean Lebel; Nikta Zarifyussefian; Mathieu Letendre-Jauniaux; Olivier Daigle; Elena Ranyuk; Johannes Van Lier; Brigitte Guérin; Roger Lecomte; Marc Massonneau; Marie-Eve Ducharme; Yves Bérubé-Lauzière

doi:10.1117/12.2005794

13 March 2013 Ultra-high sensitivity detection of bimodal probes at ultra-low noise for combined fluorescence and positron emission tomography imaging

Réjean Lebel, Nikta Zarifyussefian, Mathieu Letendre-Jauniaux, Olivier Daigle, Elena Ranyuk, Johannes Van Lier, Brigitte Guérin, Roger Lecomte, Marc Massonneau, Marie-Eve Ducharme, Yves Bérubé-Lauzière

Author Affiliations +

Proceedings Volume 8574, Multimodal Biomedical Imaging VIII; 85740M (2013) https://doi.org/10.1117/12.2005794
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Multimodal imaging is quickly becoming a standard in pre-clinical studies, and new developments have already confirmed the strength of acquiring and analyzing parallel information obtained in a single imaging session. One such application is the introduction of an internal reference moiety (e.g. radioisotope) to an activatable fluorescent probe. One of the limitations of this approach consists of working at concentrations which are within the overlapping range of sensitivities of each modality. In the case of PET/Fluorescence imaging, this range is in the order of 10^-9 nM. Working in epi-illumination fluorescence imaging at such concentrations remains challenging. Here, we present in vitro and in vivo detection limits of a new fluorescent compound.

Citation Download Citation

Réjean Lebel, Nikta Zarifyussefian, Mathieu Letendre-Jauniaux, Olivier Daigle, Elena Ranyuk, Johannes Van Lier, Brigitte Guérin, Roger Lecomte, Marc Massonneau, Marie-Eve Ducharme, and Yves Bérubé-Lauzière "Ultra-high sensitivity detection of bimodal probes at ultra-low noise for combined fluorescence and positron emission tomography imaging", Proc. SPIE 8574, Multimodal Biomedical Imaging VIII, 85740M (13 March 2013); https://doi.org/10.1117/12.2005794

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available