13 March 2013 Ultra-high sensitivity detection of bimodal probes at ultra-low noise for combined fluorescence and positron emission tomography imaging
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Proceedings Volume 8574, Multimodal Biomedical Imaging VIII; 85740M (2013) https://doi.org/10.1117/12.2005794
Event: SPIE BiOS, 2013, San Francisco, California, United States
Abstract
Multimodal imaging is quickly becoming a standard in pre-clinical studies, and new developments have already confirmed the strength of acquiring and analyzing parallel information obtained in a single imaging session. One such application is the introduction of an internal reference moiety (e.g. radioisotope) to an activatable fluorescent probe. One of the limitations of this approach consists of working at concentrations which are within the overlapping range of sensitivities of each modality. In the case of PET/Fluorescence imaging, this range is in the order of 10-9 nM. Working in epi-illumination fluorescence imaging at such concentrations remains challenging. Here, we present in vitro and in vivo detection limits of a new fluorescent compound.
© (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Réjean Lebel, Réjean Lebel, Nikta Zarifyussefian, Nikta Zarifyussefian, Mathieu Letendre-Jauniaux, Mathieu Letendre-Jauniaux, Olivier Daigle, Olivier Daigle, Elena Ranyuk, Elena Ranyuk, Johannes Van Lier, Johannes Van Lier, Brigitte Guérin, Brigitte Guérin, Roger Lecomte, Roger Lecomte, Marc Massonneau, Marc Massonneau, Marie-Eve Ducharme, Marie-Eve Ducharme, Yves Bérubé-Lauzière, Yves Bérubé-Lauzière, } "Ultra-high sensitivity detection of bimodal probes at ultra-low noise for combined fluorescence and positron emission tomography imaging", Proc. SPIE 8574, Multimodal Biomedical Imaging VIII, 85740M (13 March 2013); doi: 10.1117/12.2005794; https://doi.org/10.1117/12.2005794
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