13 March 2013 Detecting fluorescence hot-spots using mosaic maps generated from multimodal endoscope imaging
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Proceedings Volume 8575, Endoscopic Microscopy VIII; 857508 (2013) https://doi.org/10.1117/12.2002219
Event: SPIE BiOS, 2013, San Francisco, California, United States
Abstract
Fluorescence labeled biomarkers can be detected during endoscopy to guide early cancer biopsies, such as high-grade dysplasia in Barrett's Esophagus. To enhance intraoperative visualization of the fluorescence hot-spots, a mosaicking technique was developed to create full anatomical maps of the lower esophagus and associated fluorescent hot-spots. The resultant mosaic map contains overlaid reflectance and fluorescence images. It can be used to assist biopsy and document findings. The mosaicking algorithm uses reflectance images to calculate image registration between successive frames, and apply this registration to simultaneously acquired fluorescence images. During this mosaicking process, the fluorescence signal is enhanced through multi-frame averaging. Preliminary results showed that the technique promises to enhance the detectability of the hot-spots due to enhanced fluorescence signal.
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Chenying Yang, Timothy D. Soper, Eric J. Seibel, "Detecting fluorescence hot-spots using mosaic maps generated from multimodal endoscope imaging ", Proc. SPIE 8575, Endoscopic Microscopy VIII, 857508 (13 March 2013); doi: 10.1117/12.2002219; https://doi.org/10.1117/12.2002219
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