20 March 2013 Dual-channel fiber-probe for simultaneous imaging of swept source optical coherence tomography and fluorescence spectroscopy
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Abstract
We propose a dual-channel fiber scanning probe for simultaneous measurement of swept source optical coherence tomography (SS OCT) and fluorescence spectroscopy (FS) signals. For the purpose, SS OCT and FS system were combined by adopting the specially fabricated double cladding fiber (DCF) and wavelength division multiplexer (WDM) coupler, and DCF fiber was directly connected to sample arm of DCF coupler for fiber-based probe. Moreover, for sample scanning, the fiber was driven by piezoelectric bender. Since DCF has dual-channel configuration consists of core and inner cladding, both OCT and FS signals propagate through the two channels at the same time. Therefore, the suggested system enables multifunctional imaging that would make it possible to determine a more specific diagnosis. To demonstrate the feasibility of the probe, a photosensitizer injected in-vivo mice were imaged with scanning speed of 16 Hz and scanning range of 2 mm.
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Eun Jung Min, Eun Jung Min, Jae Hwi Lee, Jae Hwi Lee, Jun Geun Shin, Jun Geun Shin, Seong-Min Kwon, Seong-Min Kwon, Hyun You, Hyun You, Jung-Hoon Yoon, Jung-Hoon Yoon, Yong-Chul Kim, Yong-Chul Kim, Byeong Ha Lee, Byeong Ha Lee, } "Dual-channel fiber-probe for simultaneous imaging of swept source optical coherence tomography and fluorescence spectroscopy", Proc. SPIE 8576, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIII, 85760B (20 March 2013); doi: 10.1117/12.2003749; https://doi.org/10.1117/12.2003749
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