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19 March 2013 In vivo three-dimensional optical coherence tomography and multiphoton microscopy in a mouse model of ovarian neoplasia
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Proceedings Volume 8577, Optical Biopsy XI; 85770P (2013) https://doi.org/10.1117/12.1000273
Event: SPIE BiOS, 2013, San Francisco, California, United States
Abstract
Our goal is to use optical coherence tomography (OCT) and multiphoton microscopy (MPM) to detect early tumor development in a mouse model of ovarian neoplasia. We hope to use information regarding early tumor development to create a diagnostic test for high-risk patients. In this study we collect in vivo images using OCT, second harmonic generation and two-photon excited fluorescence from non-vinylcyclohexene diepoxide (VCD)-dosed and VCD-dosed mice. VCD causes follicular apoptosis (simulating menopause) and leads to tumor development. Using OCT and MPM we visualized the ovarian microstructure and were able to see differences between non-VCD-dosed and VCD-dosed animals. This leads us to believe that OCT and MPM may be useful for detecting changes due to early tumor development.
© (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Jennifer M. Watson, Samuel L. Marion, Photini Faith Rice, David L. Bentley, David Besselsen, Urs Utzinger, Patricia B. Hoyer, and Jennifer K. Barton "In vivo three-dimensional optical coherence tomography and multiphoton microscopy in a mouse model of ovarian neoplasia", Proc. SPIE 8577, Optical Biopsy XI, 85770P (19 March 2013); https://doi.org/10.1117/12.1000273
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