25 March 2013 Reconstruction of cerebral hemodynamics with dynamic contrast-enhanced time-resolved near-infrared measurements before and during ischemia
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Abstract
We present a dynamic contrast-enhanced near-infrared (DCE-NIR) technique that is capable of non-invasive quantification of cerebral hemodynamics in adults. The challenge of removing extracerebral contamination is overcome through the use of multi-distance time-resolved DCE-NIR combined with the kinetic deconvolution optical reconstruction (KDOR) analytical method. As proof-of-principle, cerebral blood flow, cerebral blood volume and mean transit time recovered with DCE-NIR are compared with CT perfusion values in an adult pig during normocapnia, hypocapnia, and ischemia. Measurements of blood flow acquired with DCE-NIR were compared against concomitant measurements using CT Perfusion.
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Jonathan T. Elliott, Mamadou Diop, Laura B. Morrison, Ting-Yim Lee, Keith St. Lawrence, "Reconstruction of cerebral hemodynamics with dynamic contrast-enhanced time-resolved near-infrared measurements before and during ischemia", Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85780A (25 March 2013); doi: 10.1117/12.2005128; https://doi.org/10.1117/12.2005128
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