25 March 2013 Dynamic optical breast imaging for neoadjuvant therapy monitoring
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Abstract
Near-infrared optical measurements have been shown to offer a promising non-invasive way for monitoring breast neoadjuvant chemotherapy (NAC) and predicting outcome. In this study, we extend optical measurements to capture additional hemodynamic and metabolic biomarkers revealed by dynamically imaging breast tissue during fractional mammographic compression. We are obtaining pre-treatment, day 7 and optional monthly scans in breast cancer patients undergoing NAC. The difference in hemodynamic response to compression between healthy and tumor-bearing breast decreases over the course of neoadjuvant therapy in responders compared to nearly no change in patients not responding to the chemotherapy.
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Amir Y. Sajjadi, Amir Y. Sajjadi, Christy M. Wanyo, Christy M. Wanyo, Qianqian Fang, Qianqian Fang, David A. Boas, David A. Boas, Steven J. Isakoff, Steven J. Isakoff, Stefan A. Carp, Stefan A. Carp, } "Dynamic optical breast imaging for neoadjuvant therapy monitoring", Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85780I (25 March 2013); doi: 10.1117/12.2004884; https://doi.org/10.1117/12.2004884
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