25 March 2013 Monitoring changes in tissue optical properties following interstitial photothermal therapy of ex vivo human prostate tissue
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Abstract
We are developing a method of monitoring treatment progression of interstitial photothermal therapy of focal prostate cancer using transrectal diffuse optical tomography (TRDOT) combined with transrectal 3D ultrasound (3D-TRUS). Measurements of prostate tissue optical properties were made on ex vivo human prostate samples prior to and post coagulation. Interstitial photothermal treatments were delivered to the ex vivo samples and monitored using an interstitial probe near the treatment fiber. After treatment, bulk optical properties were measured on native and coagulated zones of tissue. Changes in optical properties across the boundary between native and coagulated tissues were spatially mapped using a small diffuse reflectance probe. The optical property estimates and spatial information obtained using each method was compared.
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Robert A. Weersink, Jie He, Israel Veilleux, John Trachtenberg, Brian C. Wilson, "Monitoring changes in tissue optical properties following interstitial photothermal therapy of ex vivo human prostate tissue", Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85781G (25 March 2013); doi: 10.1117/12.2004578; https://doi.org/10.1117/12.2004578
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