25 March 2013 Hierarchical clustering method for improved prostate cancer imaging in diffuse optical tomography
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Abstract
We investigate the feasibility of trans-rectal near infrared (NIR) based diffuse optical tomography (DOT) for early detection of prostate cancer using a transrectal ultrasound (TRUS) compatible imaging probe. For this purpose, we designed a TRUS-compatible, NIR-based image system (780nm), in which the photo diodes were placed on the trans-rectal probe. DC signals were recorded and used for estimating the absorption coefficient. We validated the system using laboratory phantoms. For further improvement, we also developed a hierarchical clustering method (HCM) to improve the accuracy of image reconstruction with limited prior information. We demonstrated the method using computer simulations laboratory phantom experiments.
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Venkaiah C. Kavuri, Venkaiah C. Kavuri, Hanli Liu, Hanli Liu, } "Hierarchical clustering method for improved prostate cancer imaging in diffuse optical tomography", Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85781K (25 March 2013); doi: 10.1117/12.2005105; https://doi.org/10.1117/12.2005105
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