25 March 2013 Imaging of vascular dynamics within the foot using dynamic diffuse optical tomography to diagnose peripheral arterial disease
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Abstract
Peripheral Arterial Disease (PAD) is the narrowing of the functional area of the artery generally due to atherosclerosis. It affects between 8-12 million people in the United States and if untreated this can lead to ulceration, gangrene and ultimately amputation. The current diagnostic method for PAD is the ankle-brachial index (ABI). The ABI is a ratio of the patient’s systolic blood pressure in the foot to that of the brachial artery in the arm, a ratio below 0.9 is indicative of affected vasculature. However, this method is ineffective in patients with calcified arteries (diabetic and end-stage renal failure patients), which falsely elevates the ABI recording resulting in a false negative reading. In this paper we present our results in a pilot study to deduce optical tomography’s ability to detect poor blood perfusion in the foot. We performed an IRB approved 30 patient study, where we imaged the feet of the enrolled patients during a five stage dynamic imaging sequence. The patients were split up into three groups: 10 healthy subjects, 10 PAD patients and 10 PAD patients with diabetes and they were imaged while applying a pressure cuff to their thigh. Differences in the magnitude of blood pooling in the foot and rate at which the blood pools in the foot are all indicative of arterial disease.
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M. A. Khalil, H. K. Kim, J. W. Hoi, I. Kim, R. Dayal, G. Shrikande, A. H. Hielscher, "Imaging of vascular dynamics within the foot using dynamic diffuse optical tomography to diagnose peripheral arterial disease", Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85781M (25 March 2013); doi: 10.1117/12.2003399; https://doi.org/10.1117/12.2003399
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