25 March 2013 Target tumor hypoxia with 2-nitroimidazole-ICG dye conjugates
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In this paper, we have synthesized a second generation tumor hypoxia targeted 2-nitroimidazole-ICG conjugate using piperazine linker (2-nitro-ICG-p) and validated its performance in in vivo tumor targeting. The results have shown that tumor hypoxia can be targeted with twice higher signal strength beyond three hours post-injection while the un-targeted ICG has completely washed out. The improvement of the second generation 2-nitro-ICG-p dyes is 1.2-1.3 times over the first generation 2-nitro-ICG dyes using ethanol linker beyond 3 hours post-injection which is the optimal time-window for evaluating tumor hypoxia.
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Yan Xu, Saeid Zanganeh, Innus Mohammad, Andres Aguirre, Tianheng Wang, Yi Yang, Liisa Kuhn, Michael Smith, Quing Zhu, "Target tumor hypoxia with 2-nitroimidazole-ICG dye conjugates", Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85781Z (25 March 2013); doi: 10.1117/12.2004767; https://doi.org/10.1117/12.2004767

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