25 March 2013 Target tumor hypoxia with 2-nitroimidazole-ICG dye conjugates
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In this paper, we have synthesized a second generation tumor hypoxia targeted 2-nitroimidazole-ICG conjugate using piperazine linker (2-nitro-ICG-p) and validated its performance in in vivo tumor targeting. The results have shown that tumor hypoxia can be targeted with twice higher signal strength beyond three hours post-injection while the un-targeted ICG has completely washed out. The improvement of the second generation 2-nitro-ICG-p dyes is 1.2-1.3 times over the first generation 2-nitro-ICG dyes using ethanol linker beyond 3 hours post-injection which is the optimal time-window for evaluating tumor hypoxia.
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Yan Xu, Yan Xu, Saeid Zanganeh, Saeid Zanganeh, Innus Mohammad, Innus Mohammad, Andres Aguirre, Andres Aguirre, Tianheng Wang, Tianheng Wang, Yi Yang, Yi Yang, Liisa Kuhn, Liisa Kuhn, Michael Smith, Michael Smith, Quing Zhu, Quing Zhu, "Target tumor hypoxia with 2-nitroimidazole-ICG dye conjugates", Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85781Z (25 March 2013); doi: 10.1117/12.2004767; https://doi.org/10.1117/12.2004767


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