Development of quality control and instrumentation performance metrics for diffuse optical spectroscopic imaging instruments in the multi-center clinical environment

Samuel T. Keene; Albert E. Cerussi; Robert V. Warren; Brian Hill; Darren Roblyer; Anaїs Leproux; Amanda F. Durkin; Thomas D. O'Sullivan; Hosain Haghany; William W. Mantulin; Bruce J. Tromberg

doi:10.1117/12.2008009

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25 March 2013 Development of quality control and instrumentation performance metrics for diffuse optical spectroscopic imaging instruments in the multi-center clinical environment

Samuel T. Keene, Albert E. Cerussi, Robert V. Warren, Brian Hill, Darren Roblyer, Anaїs Leproux, Amanda F. Durkin, Thomas D. O'Sullivan, Hosain Haghany, William W. Mantulin, Bruce J. Tromberg

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Proceedings Volume 8578, Optical Tomography and Spectroscopy of Tissue X; 85782M (2013) https://doi.org/10.1117/12.2008009
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Instrument equivalence and quality control are critical elements of multi-center clinical trials. We currently have five identical Diffuse Optical Spectroscopic Imaging (DOSI) instruments enrolled in the American College of Radiology Imaging Network (ACRIN, #6691) trial located at five academic clinical research sites in the US. The goal of the study is to predict the response of breast tumors to neoadjuvant chemotherapy in 60 patients. In order to reliably compare DOSI measurements across different instruments, operators and sites, we must be confident that the data quality is comparable. We require objective and reliable methods for identifying, correcting, and rejecting low quality data. To achieve this goal, we developed and tested an automated quality control algorithm that rejects data points below the instrument noise floor, improves tissue optical property recovery, and outputs a detailed data quality report. Using a new protocol for obtaining dark-noise data, we applied the algorithm to ACRIN patient data and successfully improved the quality of recovered physiological data in some cases.

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Samuel T. Keene, Albert E. Cerussi, Robert V. Warren, Brian Hill, Darren Roblyer, Anaїs Leproux, Amanda F. Durkin, Thomas D. O'Sullivan, Hosain Haghany, William W. Mantulin, and Bruce J. Tromberg "Development of quality control and instrumentation performance metrics for diffuse optical spectroscopic imaging instruments in the multi-center clinical environment", Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85782M (25 March 2013); https://doi.org/10.1117/12.2008009

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