Trigger effect of infrared femtosecond laser irradiation on neoplasm in experimental cervical cancer

Tatyana Gening; Olga Voronova; Igor Zolotovskii; Alexey Sysoliatin; Dinara Dolgova; Tatyana Abakumova

doi:10.1117/12.2005625

15 February 2013 Trigger effect of infrared femtosecond laser irradiation on neoplasm in experimental cervical cancer

Tatyana Gening, Olga Voronova, Igor Zolotovskii, Alexey Sysoliatin, Dinara Dolgova, Tatyana Abakumova

Proceedings Volume 8579, Optical Interactions with Tissue and Cells XXIV; 85790I (2013) https://doi.org/10.1117/12.2005625
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

The present work discusses effect of infrared (IR) femtosecond laser irradiation on neoplasm of white mice with experimental cervical cancer- 5 (CC-5 on the 20th and 30th days after tumor transplantation). Tumor tissue was irradiated by femtosecond erbium doped fiber laser: the wavelength is 1.55 μm, average and peak powers are1,25 mW and 6kW, respectively, irradiation trials n=10. The average energy density (energy dose) on a tissue for two groups of animals was 0,24 J/cm² and 0,36 J/cm² for a single trial. Irradiation was followed by biochemical determination of LPO AOS parameters (“Lipid peroxidation-antioxidants” system): malondialdehyde (MDA), activity of superoxide dismutase (SOD), catalase and glutathione-reductase (GR), glutathione-S-transferase (GST). A subsequent morphological study of tumor tissue was performed. Mathematical analysis of data demonstrates a weak dependence of the studied parameters on energy dose. The latter implies the trigger effect of IR femtosecond laser irradiation on redox-dependent processes in neoplasm at experimental cervical cancer.

Citation Download Citation

Tatyana Gening, Olga Voronova, Igor Zolotovskii, Alexey Sysoliatin, Dinara Dolgova, and Tatyana Abakumova "Trigger effect of infrared femtosecond laser irradiation on neoplasm in experimental cervical cancer", Proc. SPIE 8579, Optical Interactions with Tissue and Cells XXIV, 85790I (15 February 2013); https://doi.org/10.1117/12.2005625

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