15 February 2013 Trigger effect of infrared femtosecond laser irradiation on neoplasm in experimental cervical cancer
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Abstract
The present work discusses effect of infrared (IR) femtosecond laser irradiation on neoplasm of white mice with experimental cervical cancer- 5 (CC-5 on the 20th and 30th days after tumor transplantation). Tumor tissue was irradiated by femtosecond erbium doped fiber laser: the wavelength is 1.55 μm, average and peak powers are1,25 mW and 6kW, respectively, irradiation trials n=10. The average energy density (energy dose) on a tissue for two groups of animals was 0,24 J/cm2 and 0,36 J/cm2 for a single trial. Irradiation was followed by biochemical determination of LPO AOS parameters (“Lipid peroxidation-antioxidants” system): malondialdehyde (MDA), activity of superoxide dismutase (SOD), catalase and glutathione-reductase (GR), glutathione-S-transferase (GST). A subsequent morphological study of tumor tissue was performed. Mathematical analysis of data demonstrates a weak dependence of the studied parameters on energy dose. The latter implies the trigger effect of IR femtosecond laser irradiation on redox-dependent processes in neoplasm at experimental cervical cancer.
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Tatyana Gening, Tatyana Gening, Olga Voronova, Olga Voronova, Igor Zolotovskii, Igor Zolotovskii, Alexey Sysoliatin, Alexey Sysoliatin, Dinara Dolgova, Dinara Dolgova, Tatyana Abakumova, Tatyana Abakumova, } "Trigger effect of infrared femtosecond laser irradiation on neoplasm in experimental cervical cancer", Proc. SPIE 8579, Optical Interactions with Tissue and Cells XXIV, 85790I (15 February 2013); doi: 10.1117/12.2005625; https://doi.org/10.1117/12.2005625
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