1 March 2013 On-off intermittency of thalamo-cortical neuronal network oscillations in the electroencephalogram of rodents with genetic predisposition to absence epilepsy
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Abstract
Spike-wave discharges are electroencephalographic hallmarks of absence epilepsy. Spike-wave discharges are known to originate from thalamo-cortical neuronal network that normally produces sleep spindle oscillations. Although both sleep spindles and spike-wave discharges are considered as thalamo-cortical oscillations, functional relationship between them is still uncertain. The present study describes temporal dynamics of spike-wave discharges and sleep spindles as determined in long-time electroencephalograms (EEG) recorded in WAG/Rij rat model of absence epilepsy. We have proposed the wavelet-based method for the automatic detection of spike-wave discharges, sleep spindles (10–15Hz) and 5–9Hz oscillations in EEG. It was found that non-linear dynamics of spike-wave discharges and sleep spindles fits well to the law of ’on-off intermittency’. Intermittency in sleep spindles and spike-wave discharges implies that (1) temporal dynamics of these oscillations are deterministic in nature, and (2) it might be controlled by a system-level mechanism responsible for circadian modulation of neuronal network activity.
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Alexander E. Hramov, Alexander E. Hramov, Vadim V. Grubov, Vadim V. Grubov, Alexey N. Pavlov, Alexey N. Pavlov, Evgenija Yu. Sitnikova, Evgenija Yu. Sitnikova, Alexey A. Koronovskii, Alexey A. Koronovskii, Anastasija E. Runnova, Anastasija E. Runnova, Sveltlana A. Shurugina, Sveltlana A. Shurugina, Alexey V. Ivanov, Alexey V. Ivanov, } "On-off intermittency of thalamo-cortical neuronal network oscillations in the electroencephalogram of rodents with genetic predisposition to absence epilepsy", Proc. SPIE 8580, Dynamics and Fluctuations in Biomedical Photonics X, 85801E (1 March 2013); doi: 10.1117/12.2001894; https://doi.org/10.1117/12.2001894
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