4 March 2013 Clinical feasibility study of combined opto-acoustic and ultrasonic imaging modality providing coregistered functional and anatomical maps of breast tumors
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Abstract
We report on findings from the clinical feasibility study of the ImagioTM. Breast Imaging System, which acquires two-dimensional opto-acoustic (OA) images co-registered with conventional ultrasound using a specialized duplex hand-held probe. Dual-wavelength opto-acoustic technology is used to generate parametric maps based upon total hemoglobin and its oxygen saturation in breast tissues. This may provide functional diagnostic information pertaining to tumor metabolism and microvasculature, which is complementary to morphological information obtained with conventional gray-scale ultrasound. We present co-registered opto-acoustic and ultrasonic images of malignant and benign tumors from a recent clinical feasibility study. The clinical results illustrate that the technology may have the capability to improve the efficacy of breast tumor diagnosis. In doing so, it may have the potential to reduce biopsies and to characterize cancers that were not seen well with conventional gray-scale ultrasound alone.
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Jason Zalev, Bryan Clingman, Remie J. Smith, Don Herzog, Tom Miller, A. Thomas Stavros, Sergey Ermilov, André Conjusteau, Dmitri Tsyboulski, Alexander A. Oraevsky, Kenneth Kist, N. Carol Dornbluth, Pamela Otto, "Clinical feasibility study of combined opto-acoustic and ultrasonic imaging modality providing coregistered functional and anatomical maps of breast tumors", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 858103 (4 March 2013); doi: 10.1117/12.2009112; https://doi.org/10.1117/12.2009112
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