CONFERENCE PROCEEDINGS
Advanced Search >
Home > Proceedings > Volume 8581 > Article
21 March 2013 A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle
Adam de la Zerda, Moritz F. Kircher, Jesse V. Jokerst, Cristina L. Zavaleta, Paul J. Kempen, Erik Mittra, Ken Pitter, Ruimin Huang, Carl Campos, Frezghi Habte, Robert Sinclair, Cameron W. Brennan, Ingo K. Mellinghoff, Eric C. Holland, Sanjiv S. Gambhir
Author Affiliations +
Proceedings Volume 8581, Photons Plus Ultrasound: Imaging and Sensing 2013; 85810G (2013) https://doi.org/10.1117/12.2001719
Event: SPIE BiOS, 2013, San Francisco, California, United States
Abstract
The difficulty in delineating brain tumor margins is a major obstacle in the path toward better outcomes for patients with brain tumors. Current imaging methods are often limited by inadequate sensitivity, specificity and spatial resolution. Here we show that a unique triplemodality magnetic resonance imaging - photoacoustic imaging - Raman imaging nanoparticle (termed here MPR nanoparticles), can accurately help delineate the margins of brain tumors in living mice both preoperatively and intraoperatively. The MPRs were detected by all three modalities with at least a picomolar sensitivity both in vitro and in living mice. Intravenous injection of MPRs into glioblastoma-bearing mice led to MPR accumulation and retention by the tumors, with no MPR accumulation in the surrounding healthy tissue, allowing for a noninvasive tumor delineation using all three modalities through the intact skull. Raman imaging allowed for guidance of intraoperative tumor resection, and a histological correlation validated that Raman imaging was accurately delineating the brain tumor margins. This new triple-modality– nanoparticle approach has promise for enabling more accurate brain tumor imaging and resection.
© (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Adam de la Zerda, Adam de la Zerda, Moritz F. Kircher, Moritz F. Kircher, Jesse V. Jokerst, Jesse V. Jokerst, Cristina L. Zavaleta, Cristina L. Zavaleta, Paul J. Kempen, Paul J. Kempen, Erik Mittra, Erik Mittra, Ken Pitter, Ken Pitter, Ruimin Huang, Ruimin Huang, Carl Campos, Carl Campos, Frezghi Habte, Frezghi Habte, Robert Sinclair, Robert Sinclair, Cameron W. Brennan, Cameron W. Brennan, Ingo K. Mellinghoff, Ingo K. Mellinghoff, Eric C. Holland, Eric C. Holland, Sanjiv S. Gambhir, Sanjiv S. Gambhir, "A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85810G (21 March 2013); doi: 10.1117/12.2001719; https://doi.org/10.1117/12.2001719
ACCESS THE FULL ARTICLE
PERSONAL SIGN IN
Full access may be available with your subscription
 
Forgot your username?
Forgot your password?
No SPIE account? Create an account
or Institutional Sign In via Shibboleth
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $14.40
Non-members: $18.00 ADD TO CART
PROCEEDINGS
 12 PAGES
DOWNLOAD PDF + SAVE TO MY LIBRARY
SHARE
GET CITATION
< Previous Article
|
Next Article >
KEYWORDS
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top