4 March 2013 Doppler photoacoustic and Doppler ultrasound in blood with optical contrast agent
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Abstract
Photoacoustic Doppler flowmetry as well as Doppler ultrasound were performed in acoustic resolution regime on tubes filled with flowing blood with indocyanine green (ICG) at different concentrations. The photoacoustic excitation utilized a pair of directly-modulated fiber-coupled 830nm laser-diodes, modulated with either CW or tone-bursts for depthresolved measurements. The amplitude of the Doppler peak in photoacoustic Doppler measurements was found to be proportional to the ICG concentration. Photoacoustic Doppler was measured in ICG at human safe concentrations, but not in whole blood. Comparing the results between the two modalities implied that using a wavelength with higher optical absorption may improve the photoacoustic signal in blood.
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Adi Sheinfeld, Avishay Eyal, "Doppler photoacoustic and Doppler ultrasound in blood with optical contrast agent", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85810S (4 March 2013); doi: 10.1117/12.2000906; https://doi.org/10.1117/12.2000906
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