4 March 2013 Single-cell photoacoustic thermometry
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A novel photoacoustic thermometric method is presented for simultaneously imaging cells and sensing their temperature. With 3 seconds per frame imaging speed, a temperature resolution of 0.2 °C was achieved in a photo-thermal cell heating experiment. Compared to other approaches, the photoacoustic thermometric method has the advantage of not requiring custom-developed temperature-sensitive biosensors. This feature should facilitate the conversion of single-cell thermometry into a routine lab tool and make it accessible to a much broader biological research community.
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Liang Gao, Liang Gao, Lidai Wang, Lidai Wang, Chiye Li, Chiye Li, Yan Liu, Yan Liu, Haixin Ke, Haixin Ke, Chi Zhang, Chi Zhang, Lihong V. Wang , Lihong V. Wang , } "Single-cell photoacoustic thermometry", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 858118 (4 March 2013); doi: 10.1117/12.2004063; https://doi.org/10.1117/12.2004063

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