4 March 2013 In vivo oxygen sensing using lifetime based photoacoustic measurements
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Abstract
Hypoxia is a condition where a region of tissue has less than adequate oxygen. It is of particular importance in tumor biology, as the hypoxic core of tumors has been shown to impede the effectiveness of many therapies. We demonstrate a novel method for oxygen sensing in vivo, based on the photoacoustic lifetime measurement of an oxygen sensitive probe. The experimental results derived from the main artery in the rat tail indicated that the lifetime of the probe, quantified by the photoacoustic measurement, shows a good linear relationship with the blood oxygenation level in the targeted artery.
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Aniruddha Ray, Justin Rajesh Rajian, Yong-Eun Koo Lee, Xueding Wang, Raoul Kopelman, "In vivo oxygen sensing using lifetime based photoacoustic measurements", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85811Q (4 March 2013); doi: 10.1117/12.2002758; https://doi.org/10.1117/12.2002758
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