4 March 2013 Video-rate photoacoustic microscopy of micro-vasculatures
Author Affiliations +
Abstract
We report the development of photoacoustic microscopy capable of video-rate high-resolution in-vivo imaging in deep tissue. A lightweight photoacoustic probe is made of a single-element broadband ultrasound transducer, a compact photoacoustic beam combiner, and a bright-field light delivery system. Focused broadband ultrasound detection provides a 44-μm lateral resolution and a 28-μm axial resolution. A multimode optical fiber is used to deliver laser pulses. The bright-field light delivery system can effectively improve the illumination efficiency. The photoacoustic probe weighs less than 40 grams and is mounted on a voice-coil scanner to acquire 40 cross-sectional images per second over several-mm range. The fast speed can effectively improve imaging throughput, reduce motion artifacts, and enable the visualization of highly dynamic biomedical processes. High-resolution micro-vascular imaging is successfully demonstrated.
© (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Lidai Wang, Lidai Wang, Konstantin Maslov, Konstantin Maslov, Wenxin Xing, Wenxin Xing, Alejandro Garcia-Uribe, Alejandro Garcia-Uribe, Lihong V. Wang, Lihong V. Wang, } "Video-rate photoacoustic microscopy of micro-vasculatures ", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85811T (4 March 2013); doi: 10.1117/12.2004714; https://doi.org/10.1117/12.2004714
PROCEEDINGS
6 PAGES


SHARE
Back to Top