In vivo multi-wavelength optical-resolution photoacoustic microscopy with stimulated Raman scattering fiber-laser source

Parsin Hajireza; Alexander Forbrich; Yan Jiang; Wei Shi; Roger Zemp

doi:10.1117/12.2005145

4 March 2013 In vivo multi-wavelength optical-resolution photoacoustic microscopy with stimulated Raman scattering fiber-laser source

Parsin Hajireza, Alexander Forbrich, Yan Jiang, Wei Shi, Roger Zemp

Author Affiliations +

Proceedings Volume 8581, Photons Plus Ultrasound: Imaging and Sensing 2013; 858129 (2013) https://doi.org/10.1117/12.2005145
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

In this paper we demonstrate a multi-wavelength optical resolution photoacoustic microscopy system for both phantom and in vivo imaging. Using a 1ns pulse width, 40-kHz repetition-rate ytterbium-doped fiber laser and a 3m single-mode polarization maintaining fiber, we produced numerous Raman-shifted wavelength peaks at with pulse energies between 100 and 400nJ per peak. Peak wavelengths were selected by using 10-nm linewidth bandpass filters. The capabilities of this system is shown by creating C-scan photoacoustic images of carbon fiber networks, 200μm dye-filled tubes, and Swiss Webster mouse ears at several wavelengths. Functional imaging potential was confirmed by assessing tubes filled with varying concentrations of two different dyes.

Citation Download Citation

Parsin Hajireza, Alexander Forbrich, Yan Jiang, Wei Shi, and Roger Zemp "In vivo multi-wavelength optical-resolution photoacoustic microscopy with stimulated Raman scattering fiber-laser source", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 858129 (4 March 2013); https://doi.org/10.1117/12.2005145

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