4 March 2013 In vivo multi-wavelength optical-resolution photoacoustic microscopy with stimulated Raman scattering fiber-laser source
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Abstract
In this paper we demonstrate a multi-wavelength optical resolution photoacoustic microscopy system for both phantom and in vivo imaging. Using a 1ns pulse width, 40-kHz repetition-rate ytterbium-doped fiber laser and a 3m single-mode polarization maintaining fiber, we produced numerous Raman-shifted wavelength peaks at with pulse energies between 100 and 400nJ per peak. Peak wavelengths were selected by using 10-nm linewidth bandpass filters. The capabilities of this system is shown by creating C-scan photoacoustic images of carbon fiber networks, 200μm dye-filled tubes, and Swiss Webster mouse ears at several wavelengths. Functional imaging potential was confirmed by assessing tubes filled with varying concentrations of two different dyes.
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Parsin Hajireza, Alexander Forbrich, Yan Jiang, Wei Shi, Roger Zemp, "In vivo multi-wavelength optical-resolution photoacoustic microscopy with stimulated Raman scattering fiber-laser source", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 858129 (4 March 2013); doi: 10.1117/12.2005145; https://doi.org/10.1117/12.2005145
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