4 March 2013 Blood pulse wave velocity measured by photoacoustic microscopy
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Abstract
Blood pulse wave velocity (PWV) is an important indicator for vascular stiffness. In this letter, we present electrocardiogram-synchronized photoacoustic microscopy for in vivo noninvasive quantification of the PWV in the peripheral vessels of mice. Interestingly, strong correlation between blood flow speed and ECG were clearly observed in arteries but not in veins. PWV is measured by the pulse travel time and the distance between two spot of a chose vessel, where simultaneously recorded electrocardiograms served as references. Statistical analysis shows a linear correlation between the PWV and the vessel diameter, which agrees with known physiology. Keywords: photoacoustic microscopy, photoacoustic spectroscopy, bilirubin, scattering medium.
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Chenghung Yeh, Chenghung Yeh, Song Hu, Song Hu, Konstantin Maslov, Konstantin Maslov, Lihong V. Wang, Lihong V. Wang, } "Blood pulse wave velocity measured by photoacoustic microscopy", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85812C (4 March 2013); doi: 10.1117/12.2004232; https://doi.org/10.1117/12.2004232
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