4 March 2013 All-optical photoacoustic microscopy using a MEMS scanning mirror
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It has been studied that a potential marker to obtain prognostic information about bladder cancer is tumor neoangiogenesis, which can be quantified by morphometric characteristics such as microvascular density. Photoacoustic microscopy (PAM) can render sensitive three-dimensional (3D) mapping of microvasculature, providing promise to evaluate the neoangiogenesis that is closely related to the diagnosis of bladder cancer. To ensure good image quality, it is desired to acquire bladder PAM images from its inside via the urethra, like conventional cystoscope. Previously, we demonstrated all-optical PAM systems using polymer microring resonators to detect photoacoustic signals and galvanometer mirrors for laser scanning. In this work, we build a miniature PAM system using a microelectromechanical systems (MEMS) scanning mirror, demonstrating a prototype of an endoscopic PAM head capable of high imaging quality of the bladder. The system has high resolutions of 17.5 μm in lateral direction and 19 μm in the axial direction at a distance of 5.4 mm. Images of printed grids and the 3D structure of microvasculature in animal bladders ex vivo by the system are demonstrated.
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Sung-Liang Chen, Sung-Liang Chen, Zhixing Xie, Zhixing Xie, Tao Ling, Tao Ling, Xunbin Wei, Xunbin Wei, L. Jay Guo, L. Jay Guo, Xueding Wang, Xueding Wang, "All-optical photoacoustic microscopy using a MEMS scanning mirror", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85812G (4 March 2013); doi: 10.1117/12.2002684; https://doi.org/10.1117/12.2002684

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