Transvaginal photoacoustic imaging probe and system based on a multiport fiber-optic beamsplitter and a real time imager for ovarian cancer detection

Patrick D. Kumavor; Umar Alqasemi; Behnoosh Tavakoli; Hai Li; Yi Yang; Quing Zhu

doi:10.1117/12.2004768

4 March 2013 Transvaginal photoacoustic imaging probe and system based on a multiport fiber-optic beamsplitter and a real time imager for ovarian cancer detection

Patrick D. Kumavor, Umar Alqasemi, Behnoosh Tavakoli, Hai Li, Yi Yang, Quing Zhu

Author Affiliations +

Proceedings Volume 8581, Photons Plus Ultrasound: Imaging and Sensing 2013; 85813L (2013) https://doi.org/10.1117/12.2004768
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

This paper presents a real-time transvaginal photoacoustic imaging probe for imaging human ovaries in vivo. The probe consists of a high-throughput (up to 80%) fiber-optic 1 x 19 beamsplitters, a commercial array ultrasound transducer, and a fiber protective sheath. The beamsplitter has a 940-micron core diameter input fiber and 240-micron core diameter output fibers numbering 36. The 36 small-core output fibers surround the ultrasound transducer and delivers light to the tissue during imaging. A protective sheath, modeled in the form of the transducer using a 3-D printer, encloses the transducer with array of fibers. A real-time image acquisition system collects and processes the photoacoustic RF signals from the transducer, and displays the images formed on a monitor in real time. Additionally, the system is capable of coregistered pulse-echo ultrasound imaging. In this way, we obtain both morphological and functional information from the ovarian tissue. Photoacousitc images of malignant human ovaries taken ex vivo with the probe revealed blood vascular and networks that was distinguishable from normal ovaries, making the probe potential useful for characterizing ovarian tissue.

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Patrick D. Kumavor, Umar Alqasemi, Behnoosh Tavakoli, Hai Li, Yi Yang, and Quing Zhu "Transvaginal photoacoustic imaging probe and system based on a multiport fiber-optic beamsplitter and a real time imager for ovarian cancer detection ", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85813L (4 March 2013); https://doi.org/10.1117/12.2004768

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KEYWORDS

Ovary

Transducers

Ultrasonography

Beam splitters

Imaging systems

Photoacoustic spectroscopy

Tissue optics

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