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4 March 2013 Carbon nanoparticles as a multimodal thermoacoustic and photoacoustic contrast agent
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We demonstrated the potential of carbon nanoparticles (CNPs) as exogenous contrast agents for both thermoacoustic (TA) tomography (TAT) and photoacoustic (PA) tomography (PAT). In comparison to deionized water, the CNPs provided a four times stronger signal in TAT at 3 GHz. In comparison to blood, The CNPs provided a much stronger signal in PAT over a broad wavelength range of 450-850 nm. Specifically, the maximum signal enhancement in PAT was 9.4 times stronger in the near-infrared window of 635-670 nm. In vivo blood-vessel PA imaging was performed non-invasively on a mouse femoral area. The images, captured after the tail vein injection of CNPs, show a gradual enhancement of the optical absorption in the vessels by up to 230%. The results indicate that CNPs can be potentially used as contrast agents for TAT and PAT to monitor the intravascular or extravascular pathways in clinical applications.
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Xin Cai, Lina Wu, Wenxin Xing, Jun Xia, Liming Nie, Ruiying Zhang, Gregory M. Lanza, Baozhong Shen, Dipanjan Pan, and Lihong V. Wang "Carbon nanoparticles as a multimodal thermoacoustic and photoacoustic contrast agent", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 858140 (4 March 2013);

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