4 March 2013 Combined 3D photoacoustic and 2D fluorescence imaging of indocyanine green contrast agent flow
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Abstract
Photoacoustic imaging uses laser induced ultrasound transients to generate optical absorption maps of the illuminated volume. In this work, we used a custom built photoacoustic imaging system consisting of a 60-channel transducer array, a 50 MHz data acquisition system, and an Nd:YAG pumped OPO laser, to perform simultaneous photoacoustic and fluorescence imaging. A single 780 nm laser pulse generated both ultrasound and fluorescence, enabling reconstruction of images for both modalities with near perfect temporal co-registration. The result highlighted the ability of photoacoustic imaging to supplement fluorescence data when optical scatter reduces fluorescence resolution beyond its useful range.
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Ivan Kosik, Jeffrey J. L. Carson, "Combined 3D photoacoustic and 2D fluorescence imaging of indocyanine green contrast agent flow", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 858143 (4 March 2013); doi: 10.1117/12.2005269; https://doi.org/10.1117/12.2005269
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