4 March 2013 Improving photoacoustic imaging contrast of brachytherapy seeds
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Prostate brachytherapy is a form of radiotherapy for treating prostate cancer where the radiation sources are seeds inserted into the prostate. Accurate localization of seeds during prostate brachytherapy is essential to the success of intraoperative treatment planning. The current standard modality used in intraoperative seeds localization is transrectal ultrasound. Transrectal ultrasound, however, suffers in image quality due to several factors such speckle, shadowing, and off-axis seed orientation. Photoacoustic imaging, based on the photoacoustic phenomenon, is an emerging imaging modality. The contrast generating mechanism in photoacoustic imaging is optical absorption that is fundamentally different from conventional B-mode ultrasound which depicts changes in acoustic impedance. A photoacoustic imaging system is developed using a commercial ultrasound system. To improve imaging contrast and depth penetration, absorption enhancing coating is applied to the seeds. In comparison to bare seeds, approximately 18.5 dB increase in signal-to-noise ratio as well as a doubling of imaging depth are achieved. Our results demonstrate that the coating of the seeds can further improve the discernibility of the seeds.
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Leo Pan, Leo Pan, Ali Baghani, Ali Baghani, Robert Rohling, Robert Rohling, Purang Abolmaesumi, Purang Abolmaesumi, Septimiu Salcudean, Septimiu Salcudean, Shuo Tang, Shuo Tang, "Improving photoacoustic imaging contrast of brachytherapy seeds", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85814B (4 March 2013); doi: 10.1117/12.2005787; https://doi.org/10.1117/12.2005787

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