Towards non-invasive in vivo measurements of nanoparticle concentrations using 3D optoacoustic tomography

Dmitri Tsyboulski; Anton Liopo; Richard Su; Sergei Ermilov; Sergei Bachilo; R. Bruce Weisman; Alexander A. Oraevsky

doi:10.1117/12.2008897

4 March 2013 Towards non-invasive in vivo measurements of nanoparticle concentrations using 3D optoacoustic tomography

Dmitri Tsyboulski, Anton Liopo, Richard Su, Sergei Ermilov, Sergei Bachilo, R. Bruce Weisman, Alexander A. Oraevsky

Author Affiliations +

Proceedings Volume 8581, Photons Plus Ultrasound: Imaging and Sensing 2013; 85814V (2013) https://doi.org/10.1117/12.2008897
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

In this report, we demonstrate the feasibility of using optoacoustic tomography for deducing biodistributions of nanoparticles in animal models. The redistribution of single-walled carbon nanotubes (SWCNTs) was visualized in living mice. Nanoparticle concentrations in harvested organs were measured spectroscopically using the intrinsic optical absorption and fluorescence of SWCNTs. Observed increases in optoacoustic signal brightness in tissues were compared with increases in optical absorptivity coefficients caused by SWCNT accumulation. The methodology presented in this report paves the way for measuring concentrations of optically absorbing agents in small animals using optoacoustic tomography.

Citation Download Citation

Dmitri Tsyboulski, Anton Liopo, Richard Su, Sergei Ermilov, Sergei Bachilo, R. Bruce Weisman, and Alexander A. Oraevsky "Towards non-invasive in vivo measurements of nanoparticle concentrations using 3D optoacoustic tomography", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85814V (4 March 2013); https://doi.org/10.1117/12.2008897

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