Folate receptor-mediated tumor-targeted upconversion nanocomplex for photodynamic therapy triggered by near-infrared light

Sisi Cui; Haiyan Chen; Zhiyu Qian; Wei R. Chen; Yueqing Gu

doi:10.1117/12.2003246

21 February 2013 Folate receptor-mediated tumor-targeted upconversion nanocomplex for photodynamic therapy triggered by near-infrared light

Sisi Cui, Haiyan Chen, Zhiyu Qian, Wei R. Chen, Yueqing Gu

Author Affiliations +

Proceedings Volume 8582, Biophotonics and Immune Responses VIII; 85820A (2013) https://doi.org/10.1117/12.2003246
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

In this study, we have prepared tumor-targeted hydrophilic UCNPs by coating folate-modified amphiphilic SOC polymer on the surface of OA-UNCPs through hydrophobic interaction. The produced FASOC-UCNPs have excellent optical properties and good dispersibility in aqueous solution. TEM image and FTIR spectra confirm the successful surface modification of OA-UCNPs and folate-conjugation on the UCNPs. Folate-conjugated UCNPs possess active-targeting ability mediated by FR, compared with passive-targeted SOC-UCNP taken up by tumors via the EPR effect. Singlet oxygen production in cancer cells induced by FASOC-UCNP-ZnPc demonstrates the great potential of the nanocomplex as a novel PDT agent based on UCNPs.

Citation Download Citation

Sisi Cui, Haiyan Chen, Zhiyu Qian, Wei R. Chen, and Yueqing Gu "Folate receptor-mediated tumor-targeted upconversion nanocomplex for photodynamic therapy triggered by near-infrared light", Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 85820A (21 February 2013); https://doi.org/10.1117/12.2003246

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available