21 February 2013 Folate receptor-mediated tumor-targeted upconversion nanocomplex for photodynamic therapy triggered by near-infrared light
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Proceedings Volume 8582, Biophotonics and Immune Responses VIII; 85820A (2013) https://doi.org/10.1117/12.2003246
Event: SPIE BiOS, 2013, San Francisco, California, United States
Abstract
In this study, we have prepared tumor-targeted hydrophilic UCNPs by coating folate-modified amphiphilic SOC polymer on the surface of OA-UNCPs through hydrophobic interaction. The produced FASOC-UCNPs have excellent optical properties and good dispersibility in aqueous solution. TEM image and FTIR spectra confirm the successful surface modification of OA-UCNPs and folate-conjugation on the UCNPs. Folate-conjugated UCNPs possess active-targeting ability mediated by FR, compared with passive-targeted SOC-UCNP taken up by tumors via the EPR effect. Singlet oxygen production in cancer cells induced by FASOC-UCNP-ZnPc demonstrates the great potential of the nanocomplex as a novel PDT agent based on UCNPs.
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Sisi Cui, Sisi Cui, Haiyan Chen, Haiyan Chen, Zhiyu Qian, Zhiyu Qian, Wei R. Chen, Wei R. Chen, Yueqing Gu, Yueqing Gu, } "Folate receptor-mediated tumor-targeted upconversion nanocomplex for photodynamic therapy triggered by near-infrared light", Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 85820A (21 February 2013); doi: 10.1117/12.2003246; https://doi.org/10.1117/12.2003246
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