Combined photothermal therapy and chemotherapy in cancer using HER-2 targeted PLGA nanoparticles

Anthony J McGoron; Supriya Srinivasan; Tingjun Lei; Yuan Tang; Romila Manchanda

doi:10.1117/12.2005500

21 February 2013 Combined photothermal therapy and chemotherapy in cancer using HER-2 targeted PLGA nanoparticles

Anthony J McGoron, Supriya Srinivasan, Tingjun Lei, Yuan Tang, Romila Manchanda

Proceedings Volume 8582, Biophotonics and Immune Responses VIII; 85820B (2013) https://doi.org/10.1117/12.2005500
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

We previously reported on the synergistic effects of hyperthermia and chemotherapy using doxorubicin (DOX) and Indocyanine Green (ICG). In a previous study we also explored the potential use of simultaneous entrapment of optical/imaging and chemotherapeutic agents into PLGA nanoparticles. The aim of the present study is to further decorate their surface with tumor specific monoclonal antibodies in order to achieve simultaneous therapy and diagnosis in a targeted manner. Thus, ICG was selected as an imaging agent due to its wide clinical applications and since it can also serve as hyperthermia agent. DOX was selected as the chemotherapeutic agent since it is used clinically for a large spectrum of tumors.

Citation Download Citation

Anthony J McGoron, Supriya Srinivasan, Tingjun Lei, Yuan Tang, and Romila Manchanda "Combined photothermal therapy and chemotherapy in cancer using HER-2 targeted PLGA nanoparticles", Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 85820B (21 February 2013); https://doi.org/10.1117/12.2005500

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