21 February 2013 Photothermal effects of immunologically modified carbon nanotubes
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Proceedings Volume 8582, Biophotonics and Immune Responses VIII; 85820C (2013) https://doi.org/10.1117/12.999961
Event: SPIE BiOS, 2013, San Francisco, California, United States
Abstract
Carbon nanotubes have a great potential in the biomedical applications. To use carbon nanotubes in the treatment of cancer, we synthesized an immunologically modified single-walled carbon nanotube (SWNT) using a novel immunomodifier, glycated chitosan (GC), as an effective surfactant for SWNT. This new composition SWNT-GC was stable due to the strong non-covalent binding between SWNT and GC. The structure of SWNT-GC is presented in this report. The photothermal effect of SWNT-GC was investigated under irradiation of a near-infrared laser. SWNT-GC retained the optical properties of SWNT and the immunological properties of GC. Specifically, the SWNT-GC could selectively absorb a 980-nm light and induce desirable thermal effects in tissue culture and in animals. It could also induce tumor cell destruction, controlled by the laser settings and the doses of SWNT and GC. Laser+SWNT-GC treatment could also induce strong expression of heat shock proteins on the surface of tumor cells. This immunologically modified carbon nanotube could be used for selective photothermal interactions in noninvasive tumor treatment.
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Ryan T. Griswold, Ryan T. Griswold, Brock Henderson, Brock Henderson, Jessica Goddard, Jessica Goddard, Yongqiang Tan, Yongqiang Tan, Tomas Hode, Tomas Hode, Hong Liu, Hong Liu, Robert E. Nordquist, Robert E. Nordquist, Wei R. Chen, Wei R. Chen, "Photothermal effects of immunologically modified carbon nanotubes", Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 85820C (21 February 2013); doi: 10.1117/12.999961; https://doi.org/10.1117/12.999961
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