21 February 2013 Assessments of urine cofilin-1 in patients hospitalized in the intensive care units with acute kidney injury
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Proceedings Volume 8582, Biophotonics and Immune Responses VIII; 85820N (2013) https://doi.org/10.1117/12.2001000
Event: SPIE BiOS, 2013, San Francisco, California, United States
Abstract
The actin depolymerizing factor (ADF)/cofilin protein family has been reported to be associated with ischemia induced renal disorders. Here we examine if cofilin-1 is associated with acute kidney injury (AKI). We exploited a 96-well based fiber-optic biosensor that uses conjugated gold nanoparticles and a sandwich immunoassay to detect the urine cofilin-1 level of AKI patients. The mean urine cofilin-1 level of the AKI patients was two-fold higher than that of healthy adults. The receiver operating characteristic (ROC) curve showed that cofilin-1 is a potential biomarker for discriminating AKI patients from healthy adults for intensive care patients.
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Yi-Jang Lee, Yi-Jang Lee, Cheng-Han Chao, Cheng-Han Chao, Ying-Feng Chang, Ying-Feng Chang, Chien Chou, Chien Chou, } "Assessments of urine cofilin-1 in patients hospitalized in the intensive care units with acute kidney injury", Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 85820N (21 February 2013); doi: 10.1117/12.2001000; https://doi.org/10.1117/12.2001000
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