Preparation and characterization of a drug carrier for hepatocellular carcinoma targeting

Yuxiang Ma; Yuqi Chen; Sisi Cui; Juan Zhao; Wei R. Chen; Yueqing Gu

doi:10.1117/12.2003267

22 February 2013 Preparation and characterization of a drug carrier for hepatocellular carcinoma targeting

Yuxiang Ma, Yuqi Chen, Sisi Cui, Juan Zhao, Wei R. Chen, Yueqing Gu

Proceedings Volume 8582, Biophotonics and Immune Responses VIII; 85820U (2013) https://doi.org/10.1117/12.2003267
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Asialoglycoprotein receptors distributing on the surface of hepatic parenchymal cells could specifically recognize galactose residues. Therefore, galactose residues can be applied in hepatocellar carcinoma targeted therapy through binding to the asialoglycoprotein receptors. A drug carrier containing of near infrared (NIR) fluorescence dye (MPA) and galactose was constructed by covalently conjugation process and named as GAL-MPA. The optical properties, cell viability, cell affinity and in vivo bio-distribution of this drug carrier were evaluated respectively. The results demonstrated that the drug carrier was provided with NIR fluorescence after conjugated with MPA. The low bio-toxicity and high hepatic cells affinity facilitated this drug carrier for in vivo biomedical application. Finally, the in vivo dynamic distribution of GAL-MPA confirmed this drug carrier was a promising candidate for tumor-targeting imaging and therapy.

Citation Download Citation

Yuxiang Ma, Yuqi Chen, Sisi Cui, Juan Zhao, Wei R. Chen, and Yueqing Gu "Preparation and characterization of a drug carrier for hepatocellular carcinoma targeting", Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 85820U (22 February 2013); https://doi.org/10.1117/12.2003267

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