Improved delivery of magnetic nanoparticles with chemotherapy cancer treatment

Alicia A. Petryk; Andrew J. Giustini; Rachel E. Gottesman; P. Jack Hoopes

doi:10.1117/12.2007308

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26 February 2013 Improved delivery of magnetic nanoparticles with chemotherapy cancer treatment

Alicia A. Petryk; Andrew J. Giustini; Rachel E. Gottesman; P. Jack Hoopes

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Proceedings Volume 8584, Energy-based Treatment of Tissue and Assessment VII; 85840H (2013) https://doi.org/10.1117/12.2007308
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Most nanoparticle-based cancer therapeutic strategies seek to develop an effective individual cancer cell or metastatic tumor treatment. Critical to the success of these therapies is to direct as much of the agent as possible to the targeted tissue while avoiding unacceptable normal tissue complications. In this light, three different cisplatinum/magnetic nanoparticle (mNP) administration regimens were investigated. The most important finding suggests that clinically relevant doses of cisplatinum result in a significant increase in the tumor uptake of systemically delivered mNP. This enhancement of mNP tumor uptake creates the potential for an even greater therapeutic ratio through the addition of mNP based, intracellular hyperthermia.

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Alicia A. Petryk, Andrew J. Giustini, Rachel E. Gottesman, and P. Jack Hoopes "Improved delivery of magnetic nanoparticles with chemotherapy cancer treatment", Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII, 85840H (26 February 2013); https://doi.org/10.1117/12.2007308

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